Malignant neoplasm of stomach
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
We used Progression-free survival Kaplan-Meier analysis and Western blot analysis to detect the expression of GJB4 in GC tissues and cells.
|
31692499 |
2019 |
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Gap junction beta-4 protein (GJB4), or connexin 30.3, a member of integral membrane proteins, has been shown to involve and may function as a tumor promoter in tumorigenesis.
|
31692499 |
2019 |
Stomach Carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
We used Progression-free survival Kaplan-Meier analysis and Western blot analysis to detect the expression of GJB4 in GC tissues and cells.
|
31692499 |
2019 |
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
In addition, we demonstrated that Gjb4-mediated Src activation enhanced chemoresistance of cancer cells toward gemcitabine and etoposide.
|
30177841 |
2019 |
Lung Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We found that Gjb4 expression was higher in lung tumors than normal tissues (p = 0.0026), and Gjb4 levels in blood buffy coat samples showed significant performance in diagnosing stage I-III (p = 0.002814) and stage IV (p < 0.0001) lung cancer.
|
30177841 |
2019 |
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Gjb4 serves as a novel biomarker for lung cancer and promotes metastasis and chemoresistance via Src activation.
|
30177841 |
2019 |
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Using syngeneic mouse model, we observed that Gjb4 was able to promote tumor growth.
|
30177841 |
2019 |
Secondary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overexpression or knockdown of Gjb4 increased or decreased lung metastasis of syngeneic mice, respectively.
|
30177841 |
2019 |
Malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that Gjb4 expression was higher in lung tumors than normal tissues (p = 0.0026), and Gjb4 levels in blood buffy coat samples showed significant performance in diagnosing stage I-III (p = 0.002814) and stage IV (p < 0.0001) lung cancer.
|
30177841 |
2019 |
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that Gjb4 expression was higher in lung tumors than normal tissues (p = 0.0026), and Gjb4 levels in blood buffy coat samples showed significant performance in diagnosing stage I-III (p = 0.002814) and stage IV (p < 0.0001) lung cancer.
|
30177841 |
2019 |
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
In addition, we demonstrated that Gjb4-mediated Src activation enhanced chemoresistance of cancer cells toward gemcitabine and etoposide.
|
30177841 |
2019 |
Primary malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that Gjb4 expression was higher in lung tumors than normal tissues (p = 0.0026), and Gjb4 levels in blood buffy coat samples showed significant performance in diagnosing stage I-III (p = 0.002814) and stage IV (p < 0.0001) lung cancer.
|
30177841 |
2019 |
Erythrokeratodermia variabilis
|
0.670 |
GeneticVariation
|
disease |
BEFREE |
Erythrokeratodermia variabilis et progressiva (EKV-P) is caused by mutations in either the GJB3 (Cx31) or GJB4 genes (Cx30.3).
|
29570224 |
2019 |
Erythrokeratodermia variabilis
|
0.670 |
GeneticVariation
|
disease |
BEFREE |
Erythrokeratodermia variabilis et progressiva (EKVP) is a genodermatosis with clinical and genetic heterogeneity, most often transmitted in an autosomal dominant manner, caused by mutations in GJB3 and GJB4 genes encoding connexins (Cx)31 and 30.3, respectively.In this issue, Boyden et al.
|
25964267 |
2015 |
Skin Diseases, Genetic
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Erythrokeratodermia variabilis et progressiva (EKVP) is a genodermatosis with clinical and genetic heterogeneity, most often transmitted in an autosomal dominant manner, caused by mutations in GJB3 and GJB4 genes encoding connexins (Cx)31 and 30.3, respectively.In this issue, Boyden et al.
|
25964267 |
2015 |
Nonsyndromic Deafness
|
0.020 |
Biomarker
|
disease |
BEFREE |
On the basis of the above results, it was hypothesized that GJB4 may be a genetic risk factor for the development of nonsyndromic hearing loss and the data from the present study can be used to direct the clinical evaluation and effectively manage the care of families of children with GJB4.
|
25333454 |
2015 |
Erythrokeratodermia variabilis
|
0.670 |
GermlineCausalMutation
|
disease |
ORPHANET |
Novel mutation in GJB4 gene (connexin 30.3) in a family with erythrokeratodermia variabilis.
|
23037955 |
2013 |
ERYTHROKERATODERMIA VARIABILIS ET PROGRESSIVA 2
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Novel mutation in GJB4 gene (connexin 30.3) in a family with erythrokeratodermia variabilis.
|
23037955 |
2013 |
Erythrokeratodermia variabilis
|
0.670 |
Biomarker
|
disease |
BEFREE |
Mutations associated with EKV have been identified in the connexin (Cx) genes GJB3 (Cx31) and GJB4 (Cx30.3), however, several cases of EKV have been tested negative for mutations in these two Cx genes.
|
22266302 |
2012 |
ERYTHROKERATODERMIA VARIABILIS ET PROGRESSIVA 2
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Mutation analysis of GJB3 and GJB4 in Chinese patients with erythrokeratodermia variabilis.
|
21950330 |
2012 |
Erythrokeratoderma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Erythrokeratoderma variabilis (EKV) is a rare disorder of cornification usually associated with dominant mutations in the genes GJB3 and GJB4, which code for connexin (Cx)31 and Cx30.3, respectively, and contribute to the formation of functional gap junctions in the epidermis.
|
21564177 |
2011 |
Nonsyndromic Deafness
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest the variants of GJC3, GJB4, and GJB3 may be the common genetic risk factor, after variants of GJB2, for the development of nonsyndromic HL in Taiwan.
|
20593197 |
2010 |
Inherited hearing loss
|
0.020 |
Biomarker
|
disease |
BEFREE |
Mutations in connexin genes including GJB2 (Cx26), GJB3 (Cx31), GJB4 (Cx30.3), GJB6 (Cx30) and GJA1 (Cx43) are responsible for various dermatological syndromes and/or inherited hearing loss, frequently showing overlapping phenotypes.
|
19416251 |
2009 |
Erythrokeratodermia variabilis
|
0.670 |
GeneticVariation
|
disease |
BEFREE |
Apparently, the same GJB4 mutation may cause either an EKV or a PSEK phenotype.
|
19291775 |
2009 |
ERYTHROKERATODERMIA VARIABILIS ET PROGRESSIVA 2
|
0.600 |
GeneticVariation
|
disease |
UNIPROT |
The missense mutation G12D in connexin30.3 can cause both erythrokeratodermia variabilis of Mendes da Costa and progressive symmetric erythrokeratodermia of Gottron.
|
19291775 |
2009 |